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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NEDD4L All Species: 18.18
Human Site: S479 Identified Species: 33.33
UniProt: Q96PU5 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q96PU5 NP_001138436.1 975 111932 S479 D T L S N P Q S P Q P S P Y N
Chimpanzee Pan troglodytes XP_001140254 911 104904 N479 M R S K T S L N P N D L G P L
Rhesus Macaque Macaca mulatta XP_001088661 1010 115306 S514 D T L S N P Q S P Q P S P Y N
Dog Lupus familis XP_533393 1027 117927 S531 D T L S N P Q S P Q P S P Y N
Cat Felis silvestris
Mouse Mus musculus Q8CFI0 1004 115400 S508 D T L S N P Q S P Q P S P Y N
Rat Rattus norvegicus Q62940 887 102376 G473 E E R T H T D G R V F F I N H
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511197 1255 141275 P639 S H Q N I Q S P P T P S N F D
Chicken Gallus gallus XP_424462 1045 119140 S549 D T L S N P Q S P Q P S P Y N
Frog Xenopus laevis Q2TAS2 751 86306 C357 P P Q V V S L C Q L P D E V E
Zebra Danio Brachydanio rerio A9JRZ0 765 87445 G371 A Q S V V S P G N L P E D P E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VVI3 1007 114856 P518 E E D N A A V P P M E Q N T G
Honey Bee Apis mellifera XP_395191 782 90150 R387 T T Q W E D P R M S N P Q I A
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P39940 809 91798 W415 H N T K T T T W D D P R L P S
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 93.4 92.4 90.8 N.A. 94.3 48 N.A. 43.9 85.6 34.1 34.3 N.A. 47.2 49.4 N.A. N.A.
Protein Similarity: 100 93.4 93.7 92.2 N.A. 95.6 60 N.A. 54 88.4 49 49.5 N.A. 61.8 61.1 N.A. N.A.
P-Site Identity: 100 6.6 100 100 N.A. 100 0 N.A. 20 100 6.6 6.6 N.A. 6.6 6.6 N.A. N.A.
P-Site Similarity: 100 13.3 100 100 N.A. 100 26.6 N.A. 40 100 6.6 6.6 N.A. 20 6.6 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 37 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 52.9 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 0 0 8 8 0 0 0 0 0 0 0 0 8 % A
% Cys: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % C
% Asp: 39 0 8 0 0 8 8 0 8 8 8 8 8 0 8 % D
% Glu: 16 16 0 0 8 0 0 0 0 0 8 8 8 0 16 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 8 8 0 8 0 % F
% Gly: 0 0 0 0 0 0 0 16 0 0 0 0 8 0 8 % G
% His: 8 8 0 0 8 0 0 0 0 0 0 0 0 0 8 % H
% Ile: 0 0 0 0 8 0 0 0 0 0 0 0 8 8 0 % I
% Lys: 0 0 0 16 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 39 0 0 0 16 0 0 16 0 8 8 0 8 % L
% Met: 8 0 0 0 0 0 0 0 8 8 0 0 0 0 0 % M
% Asn: 0 8 0 16 39 0 0 8 8 8 8 0 16 8 39 % N
% Pro: 8 8 0 0 0 39 16 16 62 0 70 8 39 24 0 % P
% Gln: 0 8 24 0 0 8 39 0 8 39 0 8 8 0 0 % Q
% Arg: 0 8 8 0 0 0 0 8 8 0 0 8 0 0 0 % R
% Ser: 8 0 16 39 0 24 8 39 0 8 0 47 0 0 8 % S
% Thr: 8 47 8 8 16 16 8 0 0 8 0 0 0 8 0 % T
% Val: 0 0 0 16 16 0 8 0 0 8 0 0 0 8 0 % V
% Trp: 0 0 0 8 0 0 0 8 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 39 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _